Oral supplementation with L-homoarginine in young volunteers.

ABSTRACT:

Aims

Low blood concentrations of the naturally occurring amino acid L-homoarginine (L-hArg) are related to impaired cardiovascular outcome and mortality in humans and animals. L-hArg is a weak substrate of nitric oxide synthase and an inhibitor of arginases in vitro. The aim of our study was to obtain kinetic and dynamic data after oral L-hArg supplementation.

Methods

In a double-blind, randomized, placebo-controlled crossover study, 20 young volunteers received 125 mg L-hArg once daily for 4 weeks. Kinetic parameters (C_max , T_max and AUC_0-24h ) were calculated after ingestion of single and multiple doses of oral supplementation as primary endpoint. Secondary endpoints that were evaluated were routine laboratory, L-arginine, asymmetric dimeth

SUBMITTER: Atzler D 

PROVIDER: S-EPMC5099544 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature