Quantitative model for the blood pressure-lowering interaction of valsartan and amlodipine.

ABSTRACT:

Aims

The objective of this study was to develop a population pharmacokinetic (PK) and pharmacodynamic (PD) model to quantitatively describe the antihypertensive effect of combined therapy with amlodipine and valsartan.

Methods

PK modelling was used with data collected from 48 healthy volunteers receiving a single dose of combined formulation of 10 mg amlodipine and 160 mg valsartan. Systolic (SBP) and diastolic blood pressure (DBP) were recorded during combined administration. SBP and DBP data for each drug alone were gathered from the literature. PKPD models of each drug and for combined administration were built with NONMEM 7.3.

Results

A two-compartment model with zero order absorption best described the PK data of both drugs. Amlodipine and valsartan monotherapy e

SUBMITTER: Heo YA 

PROVIDER: S-EPMC5099563 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature