Contribution of oxytocin receptor polymorphisms to amygdala activation in schizophrenia spectrum disorders.

ABSTRACT:

Background

Oxytocin has been proposed to mediate amygdala dysfunction associated with altered emotion processing in schizophrenia, but the contribution of oxytocin pathway genes is yet to be investigated.

Aims

To identify potential different contributions of three oxytocin receptor polymorphisms (rs53576, rs237902 and rs2254298) between patients with schizophrenia spectrum disorders (SCZ), affective spectrum disorders (AD) and healthy controls (HC).

Method

In a total of 346 participants (104 with SCZ, 100 with AD, and 142 HC) underwent genotyping and functional magnetic resonance imaging (fMRI) during an emotional faces matching paradigm. Genetic association analyses were performed to test the possible effects on task-induced BOLD amygdala response to fearful/angry fa

SUBMITTER: Haram M 

PROVIDER: S-EPMC5099986 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature