Cystatin-related epididymal spermatogenic subgroup members are part of an amyloid matrix and associated with extracellular vesicles in the mouse epididymal lumen.
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ABSTRACT:
SUBMITTER: Whelly S
PROVIDER: S-EPMC5099997 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Publications
Cystatin-related epididymal spermatogenic subgroup members are part of an amyloid matrix and associated with extracellular vesicles in the mouse epididymal lumen.
Whelly Sandra S Muthusubramanian Archana A Powell Jonathan J Johnson Seethal S Hastert Mary Catherine MC Cornwall Gail A GA
Molecular human reproduction 20160721 11
<h4>Study question</h4>Do the CRES (cystatin-related epididymal spermatogenic) subgroup members, including CRES2, CRES3 and cystatin E2, contribute to the formation of a nonpathological, functional amyloid matrix in the mouse epididymal lumen?<h4>Summary answer</h4>CRES2, CRES3 and cystatin E2 self-assemble with different aggregation properties into amyloids in vitro, are part of a common amyloid matrix in the mouse epididymal lumen and are present in extracellular vesicles.<h4>What is known alr ...[more]
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