Evolution of Protein Domain Repeats in Metazoa.

ABSTRACT: Repeats are ubiquitous elements of proteins and they play important roles for cellular function and during evolution. Repeats are, however, also notoriously difficult to capture computationally and large scale studies so far had difficulties in linking genetic causes, structural properties and evolutionary trajectories of protein repeats. Here we apply recently developed methods for repeat detection and analysis to a large dataset comprising over hundred metazoan genomes. We find that repeats in larger protein families experience generally very few insertions or deletions (indels) of repeat units but there is also a significant fraction of noteworthy volatile outliers with very high indel rates. Analysis of structural data indicates that repeats with an open structure and independently fol

SUBMITTER: Schuler A 

PROVIDER: S-EPMC5100051 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature