Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation.

ABSTRACT:

Background

The transcription factor SOX10 is essential for all stages of Schwann cell development including myelination. SOX10 cooperates with other transcription factors to activate the expression of key myelin genes in Schwann cells and is therefore a context-dependent, pro-myelination transcription factor. As such, the identification of genes regulated by SOX10 will provide insight into Schwann cell biology and related diseases. While genome-wide studies have successfully revealed SOX10 target genes, these efforts mainly focused on myelinating stages of Schwann cell development. We propose that less-biased approaches will reveal novel functions of SOX10 outside of myelination.

Results

We developed a stringent, computational-based screen for genome-wide identification of S

SUBMITTER: Gopinath C 

PROVIDER: S-EPMC5100263 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature