Toward the promise of microRNAs - Enhancing reproducibility and rigor in microRNA research.

ABSTRACT: The fields of applied and translational microRNA research have exploded in recent years as microRNAs have been implicated across a spectrum of diseases. MicroRNA biomarkers, microRNA therapeutics, microRNA regulation of cellular physiology and even xenomiRs have stimulated great interest, which have brought many researchers into the field. Despite many successes in determining general mechanisms of microRNA generation and function, the application of microRNAs in translational areas has not had as much success. It has been a challenge to localize microRNAs to a given cell type within tissues and assay them reliably. At supraphysiologic levels, microRNAs may regulate hosts of genes that are not the physiologic biochemical targets. Thus the applied and translational microRNA literature is fi

SUBMITTER: Witwer KW 

PROVIDER: S-EPMC5100345 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature