Sir2 regulates stability of repetitive domains differentially in the human fungal pathogen Candida albicans.

ABSTRACT: DNA repeats, found at the ribosomal DNA locus, telomeres and subtelomeric regions, are unstable sites of eukaryotic genomes. A fine balance between genetic variability and genomic stability tunes plasticity of these chromosomal regions. This tuning mechanism is particularly important for organisms such as microbial pathogens that utilise genome plasticity as a strategy for adaptation. For the first time, we analyse mechanisms promoting genome stability at the rDNA locus and subtelomeric regions in the most common human fungal pathogen: Candida albicans In this organism, the histone deacetylase Sir2, the master regulator of heterochromatin, has acquired novel functions in regulating genome stability. Contrary to any other systems analysed, C. albicans Sir2 is largely dispensable for repress

SUBMITTER: Freire-Beneitez V 

PROVIDER: S-EPMC5100595 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature