Multipronged regulatory functions of a novel endonuclease (TieA) from Helicobacter pylori.

ABSTRACT: Helicobacter pylori portrays a classical paradigm of persistent bacterial infections. A well balanced homeostasis of bacterial effector functions and host responses is purported to be the key in achieving long term colonization in specific hosts. H. pylori nucleases have been shown to assist in natural transformation, but their role in virulence and colonization remains elusive. Therefore, it is imperative to understand the involvement of these nucleases in the pathogenesis of H. pylori Here, we report the multifaceted role of a TNFR-1 interacting endonuclease A (TieA) from H. pylori. tieA expression is differentially regulated in response to environmental stress and post adherence to gastric epithelial cells. Studies with isogenic knockouts of tieA revealed it to be a secretory protein wh

SUBMITTER: Devi S 

PROVIDER: S-EPMC5100599 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature