Cigarette smoking behaviour and blood metabolomics.

ABSTRACT:

Background

Identifying circulating metabolites related to cigarette smoking may provide insight into the biological mechanisms of smoking-related diseases and the nature of addiction. However, previous studies are limited, generally small, and have largely targeted a priori metabolites.

Methods

We examined associations between cigarette smoking and metabolites using an untargeted metabolomics approach in 892 men and women from four studies including participants from Italy, USA, China and Finland. We examined associations between individual log-transformed metabolites and two key smoking phenotypes (current smoking status and cigarettes per day [cig/day]) using linear regression. Fixed-effect meta-analysis was used to combine results across studies. Strict Bonferroni thresho

SUBMITTER: Gu F 

PROVIDER: S-EPMC5100605 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature