Cumulative consumption of branched-chain amino acids and incidence of type 2 diabetes.

ABSTRACT:

Background

Plasma branched-chain amino acids (BCAAs, including leucine, isoleucine and valine) were recently related to risk of type 2 diabetes (T2D). Dietary intake is the only source of BCAAs; however, little is known about whether habitual dietary intake of BCAAs affects risk of T2D.

Methods

We assessed associations between cumulative consumption of BCAAs and risk of T2D among participants from three prospective cohorts: the Nurses' Health Study (NHS; followed from 1980 to 2012); NHS II (followed from 1991 to 2011); and the Health Professionals Follow-up Study (HPFS; followed from 1986 to 2010).

Results

We documented 16 097 incident T2D events during up to 32 years of follow-up. After adjustment for demographics and traditional risk factors, higher total BCAA intak

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC5100612 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature