High-resolution metabolomics of occupational exposure to trichloroethylene.

ABSTRACT:

Background

Occupational exposure to trichloroethylene (TCE) has been linked to adverse health outcomes including non-Hodgkin's lymphoma and kidney and liver cancer; however, TCE's mode of action for development of these diseases in humans is not well understood.

Methods

Non-targeted metabolomics analysis of plasma obtained from 80 TCE-exposed workers [full shift exposure range of 0.4 to 230 parts-per-million of air (ppm_a)] and 95 matched controls were completed by ultra-high resolution mass spectrometry. Biological response to TCE exposure was determined using a metabolome-wide association study (MWAS) framework, with metabolic changes and plasma TCE metabolites evaluated by dose-response and pathway enrichment. Biological perturbations were then linked to immunol

SUBMITTER: Walker DI 

PROVIDER: S-EPMC5100622 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature