Quantitative in vivo neurochemical profiling in humans: where are we now?

ABSTRACT: Proton nuclear magnetic resonance spectroscopy of biofluids has become one of the key techniques for metabolic profiling and phenotyping. This technique has been widely used in a number of epidemiological studies and in a variety of health disorders. However, its utilization in brain disorders is limited due to the blood-brain barrier, which not only protects the brain from unwanted substances in the blood, but also substantially limits the potential of finding biomarkers for neurological disorders in serum. This review article focuses on the potential of localized in vivo proton magnetic resonance spectroscopy (¹H-MRS) for non-invasive neurochemical profiling in the human brain. First, methodological aspects of ¹H-MRS (data acquisition, processing and metabolite quan

SUBMITTER: McKay J 

PROVIDER: S-EPMC5100624 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature