Metabolic signatures of birthweight in 18 288 adolescents and adults.

ABSTRACT:

Background

Lower birthweight is associated with increased susceptibility to cardiometabolic diseases in adulthood, but the underlying molecular pathways are incompletely understood. We examined associations of birthweight with a comprehensive metabolic profile measured in adolescents and adults.

Methods

High-throughput nuclear magnetic resonance metabolomics and biochemical assays were used to quantify 87 circulating metabolic measures in seven cohorts from Finland and the UK, comprising altogether 18 288 individuals (mean age 26 years, range 15-75). Metabolic associations with birthweight were assessed by linear regression models adjusted for sex, gestational age and age at blood sampling. The metabolic associations with birthweight were compared with the corresponding asso

SUBMITTER: Wurtz P 

PROVIDER: S-EPMC5100627 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature