Female advantage in verbal memory: Evidence of sex-specific cognitive reserve.

ABSTRACT:

Objective

We investigated sex differences in verbal memory across different levels of neural dysfunction, measured by temporal lobe glucose metabolic rates (TLGluMR).

Methods

Three hundred ninety controls and 672 participants with amnestic mild cognitive impairment (aMCI) and 254 with Alzheimer disease (AD) dementia from the Alzheimer's Disease Neuroimaging Initiative completed the Rey Auditory Verbal Learning Test (RAVLT) and [¹⁸F]-fluorodeoxyglucose-PET. Cross-sectional analyses were conducted using linear regression to examine the sex by TLGluMR interaction on RAVLT performance in the overall sample and within diagnostic groups adjusting for age, education, and APOE ε4 genotype.

Results

Across groups, female sex and higher TLGluMR and their interaction w

SUBMITTER: Sundermann EE 

PROVIDER: S-EPMC5100712 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature