Conformity analysis to demonstrate reproducibility of target volumes for Margin-Intense Stereotactic Radiotherapy for borderline-resectable pancreatic cancer.

ABSTRACT:

Background and purpose

Margin-directed neoadjuvant radiotherapy for borderline-resectable pancreatic cancer (BRPC) aims to facilitate clear surgical margins. A systematic method was developed for definition of a boost target volume prior to a formal phase-I study.

Material and methods

Reference structures were defined by two oncologists and one radiologist, target structures were submitted by eight oncologist investigators and compared using conformity indices. Resultant risk of duodenal bleed (NTCP) was modelled.

Results

For GTV, reference volume was 2.1cm³ and investigator mean was 6.03cm³ (95% CI 3.92-8.13cm³), for boost volume 1.1cm³ and 1.25cm³ (1.02-1.48cm³). Mean Dice conformity coefficient for G

SUBMITTER: Holyoake DL 

PROVIDER: S-EPMC5100802 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature