Transcriptome Pathway Analysis of Pathological and Physiological Aldosterone-Producing Human Tissues.

ABSTRACT: Primary aldosteronism is present in ≈10% of hypertensives. We previously performed a microarray assay on aldosterone-producing adenomas and their paired zona glomerulosa and fasciculata. Confirmation of top genes validated the study design and functional experiments of zona glomerulosa selective genes established the role of the encoded proteins in aldosterone regulation. In this study, we further analyzed our microarray data using AmiGO 2 for gene ontology enrichment and Ingenuity Pathway Analysis to identify potential biological processes and canonical pathways involved in pathological and physiological aldosterone regulation. Genes differentially regulated in aldosterone-producing adenoma and zona glomerulosa were associated with steroid metabolic processes gene ontology terms. Terms re

SUBMITTER: Zhou J 

PROVIDER: S-EPMC5100803 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature