Depletion of Shine-Dalgarno Sequences Within Bacterial Coding Regions Is Expression Dependent.

ABSTRACT: Efficient and accurate protein synthesis is crucial for organismal survival in competitive environments. Translation efficiency (the number of proteins translated from a single mRNA in a given time period) is the combined result of differential translation initiation, elongation, and termination rates. Previous research identified the Shine-Dalgarno (SD) sequence as a modulator of translation initiation in bacterial genes, while codon usage biases are frequently implicated as a primary determinant of elongation rate variation. Recent studies have suggested that SD sequences within coding sequences may negatively affect translation elongation speed, but this claim remains controversial. Here, we present a metric to quantify the prevalence of SD sequences in coding regions. We analyze hundre

SUBMITTER: Yang C 

PROVIDER: S-EPMC5100845 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature