Divergent DNA Methylation Provides Insights into the Evolution of Duplicate Genes in Zebrafish.

ABSTRACT: The evolutionary mechanism, fate and function of duplicate genes in various taxa have been widely studied; however, the mechanism underlying the maintenance and divergence of duplicate genes in Danio rerio remains largely unexplored. Whether and how the divergence of DNA methylation between duplicate pairs is associated with gene expression and evolutionary time are poorly understood. In this study, by analyzing bisulfite sequencing (BS-seq) and RNA-seq datasets from public data, we demonstrated that DNA methylation played a critical role in duplicate gene evolution in zebrafish. Initially, we found promoter methylation of duplicate genes generally decreased with evolutionary time as measured by synonymous substitution rate between paralogous duplicates (Ks). Importantly, promoter m

SUBMITTER: Zhong Z 

PROVIDER: S-EPMC5100857 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature