Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs.

ABSTRACT: Neuroimaging of spontaneous, resting-state infraslow (<0.1 Hz) brain activity has been used to reveal the regional functional organization of the brain and may lead to the identification of novel biomarkers of neurological disease. However, these imaging studies generally rely on indirect measures of neuronal activity and the nature of the neuronal activity correlate remains unclear. Here we show, using wide-field, voltage-sensitive dye imaging, the mesoscale spatiotemporal structure and pharmacological dependence of spontaneous, infraslow cortical activity in anaesthetized and awake mice. Spontaneous infraslow activity is regionally distinct, correlates with electroencephalography and local field potential recordings, and shows bilateral symmetry between cortical hemispheres. Infraslow ac

SUBMITTER: Chan AW 

PROVIDER: S-EPMC5101061 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature