Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease.

ABSTRACT: Although chronic graft-versus-host disease (CGVHD) is the primary nonrelapse complication of allogeneic transplantation, understanding of its pathogenesis is limited. To identify the main operant pathways across the spectrum of CGVHD, we analyzed gene expression in circulating monocytes, chosen as in situ systemic reporter cells. Microarrays identified two interrelated pathways: 1) IFN-inducible genes, and 2) innate receptors for cellular damage. Corroborating these with multiplex RNA quantitation, we found that multiple IFN-inducible genes (affecting lymphocyte trafficking, differentiation, and Ag presentation) were concurrently upregulated in CGVHD monocytes compared with normal subjects and non-CGVHD control patients. IFN-inducible chemokines were elevated in both lichenoid and scleroti

SUBMITTER: Hakim FT 

PROVIDER: S-EPMC5101132 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature