Maternal obesity programs mitochondrial and lipid metabolism gene expression in infant umbilical vein endothelial cells.

ABSTRACT:

Background/objectives

Maternal obesity increases risk for childhood obesity, but molecular mechanisms are not well understood. We hypothesized that primary umbilical vein endothelial cells (HUVEC) from infants of overweight and obese mothers would harbor transcriptional patterns reflecting offspring obesity risk.

Subjects/methods

In this observational cohort study, we recruited 13 lean (pre-pregnancy body mass index (BMI) <25.0 kg m^-2) and 24 overweight-obese ('ov-ob', BMI⩾25.0 kg m^-2) women. We isolated primary HUVEC, and analyzed both gene expression (Primeview, Affymetrix) and cord blood levels of hormones and adipokines.

Results

A total of 142 transcripts were differentially expressed in HUVEC from infants of overweight-obese mothers (false d

SUBMITTER: Costa SM 

PROVIDER: S-EPMC5101152 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature