Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration.

ABSTRACT: The use of nondepleting Abs specific for CD4 and CD8 is an effective strategy to tolerize CD4⁺ and CD8⁺ T cells in a tissue-specific manner. We reported that coreceptor therapy reverses diabetes in new onset NOD mice. A striking feature of coreceptor-induced remission is the purging of T cells from the pancreatic lymph nodes (PLN) and islets of NOD mice. Evidence indicates that Abs binding to the coreceptors promotes T cell egress from these tissues. The present study examined how coreceptor therapy affects the migration of CD4⁺ T cells residing in the PLN of NOD mice. Anti-CD4 Ab treatment resulted in an increased frequency of PLN but not splenic CD4⁺ T cells that exhibited a polarized morphology consistent with a migratory phenotype. Furthermor

SUBMITTER: Morillon YM 

PROVIDER: S-EPMC5101163 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature