Food image-induced brain activation is not diminished by insulin infusion.

ABSTRACT:

Background/objectives

The obesity epidemic appears to be driven in large part by our modern environment inundated by food cues, which may influence our desire to eat. Although insulin decreases food intake in both animals and humans, the effect of insulin on motivation for food in the presence of food cues is not known. Therefore, the aim of this study was to evaluate the effect of an intravenous insulin infusion on the brain response to visual food cues, hunger and food craving in non-obese human subjects.

Subjects/methods

Thirty-four right-handed healthy non-obese subjects (19F/15M, age: 29±8 years.; BMI: 23.1±2.1 kg m^-2) were divided in two groups matched by age and BMI; the insulin group (18 subjects) underwent a hyperinsulinemic-euglycemic-clamp, and the cont

SUBMITTER: Belfort-DeAguiar R 

PROVIDER: S-EPMC5101182 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature