Reproducibility and Bias in Healthy Brain Segmentation: Comparison of Two Popular Neuroimaging Platforms.

ABSTRACT: We evaluated and compared the performance of two popular neuroimaging processing platforms: Statistical Parametric Mapping (SPM) and FMRIB Software Library (FSL). We focused on comparing brain segmentations using Kirby21, a magnetic resonance imaging (MRI) replication study with 21 subjects and two scans per subject conducted only a few hours apart. We tested within- and between-platform segmentation reliability both at the whole brain and in 10 regions of interest (ROIs). For a range of fixed probability thresholds we found no differences between-scans within-platform, but large differences between-platforms. We have also found very large differences between- and within-platforms when probability thresholds were changed. A randomized blinded reader study indicated that: (1) SPM and FSL pe

SUBMITTER: Tudorascu DL 

PROVIDER: S-EPMC5101202 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature