The development of bronchiectasis on chest computed tomography in children with cystic fibrosis: can pre-stages be identified?

ABSTRACT:

Objective

Bronchiectasis is an important component of cystic fibrosis (CF) lung disease but little is known about its development. We aimed to study the development of bronchiectasis and identify determinants for rapid progression of bronchiectasis on chest CT.

Methods

Forty-three patients with CF with at least four consecutive biennial volumetric CTs were included. Areas with bronchiectasis on the most recent CT were marked as regions of interest (ROIs). These ROIs were generated on all preceding CTs using deformable image registration. Observers indicated whether: bronchiectasis, mucus plugging, airway wall thickening, atelectasis/consolidation or normal airways were present in the ROIs.

Results

We identified 362 ROIs on the most recent CT. In 187 (51.7 %) ROIs bron

SUBMITTER: Tepper LA 

PROVIDER: S-EPMC5101271 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature