Toxicity of antimony, copper, cobalt, manganese, titanium and zinc oxide nanoparticles for the alveolar and intestinal epithelial barrier cells in vitro.

ABSTRACT: Heavy metals are found naturally on Earth and exposure to them in the living environment is increasing as a consequence of human activity. The toxicity of six different metal oxide nanoparticles (NP) at different points in time was compared using resazurin assay. After incubating Caco2 and A549 cells with 100 μg/mL of Sb₂O₃, Mn₃O₄ and TiO₂ nanoparticles (NPs) for 24 h no toxic effects were observed while Co₃O₄ and ZnO NPs had moderate effects and CuO NPs were toxic below 100 μg/mL (24 h EC₂₅ = 11 for A549 and 71 μg/mL for Caco2). The long-term monitoring (up to 9 days) of cells to NPs revealed that the toxic effects of Mn₃O₄ and Sb₂O₃ NPs remarkably increased

SUBMITTER: Titma T 

PROVIDER: S-EPMC5101306 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature