Preferential loss of gut-homing α4β7 CD4⁺ T cells and their circulating functional subsets in acute HIV-1 infection.

ABSTRACT: Preferential infection and depletion of gut-homing α4β7 CD4⁺ T cells in the blood are observed in chronic HIV/SIV infection. The dynamic change in gut-homing α4β7 CD4⁺ T cells and their functional subsets during the acute stages of HIV-1 infection are less documented. Therefore, we conducted a cohort study to investigate whether acute HIV-1 infection induced abnormalities in gut-homing α4β7 CD4⁺ T cells and their functional subsets. We examined the frequency, absolute number, and functionality of gut-homing α4β7 CD4⁺ T cells in 26 acute HIV-1-infected patients compared with 20 healthy individuals. We found that circulating gut-homing α4β7 CD4⁺ T cells were preferentially depleted during acute HIV-1 infection and were positively correla

SUBMITTER: Lu X 

PROVIDER: S-EPMC5101442 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature