Radiation Damage in XFEL: Case study from the oxygen-evolving complex of Photosystem II.

ABSTRACT: Structural changes induced by radiation damage in X-ray crystallography hinder the ability to understand the structure/function relationship in chemical reactions. Serial femtosecond crystallography overcomes this problem by exposing the sample to very short and intense laser pulse leading to measurement before destruction. Here we use molecular modeling to map the radiation damage during the 10-50 fs to the intensity, the energy and the time duration of the laser pulse on the oxygen-evolving complex (OEC) of photosystem II. In the model, the nuclei move classically in a fully quantum potential created by electron density under the effect of strong laser pulse in the Ehrenfest dynamics regime. The results show that the Mn-Mn and Mn-Ca distances are less affected by radiation damage due to

SUBMITTER: Amin M 

PROVIDER: S-EPMC5101503 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature