Lactate is a potent inhibitor of the capsaicin receptor TRPV1.

ABSTRACT: Tissue ischemia results in an accumulation of lactate and local or systemic lactic acidosis. In nociceptive sensory neurons, lactate was reported to sensitize or activate the transient receptor potential ion channel TRPA1 and acid-sensing ion channels (ASICs). However, it is unclear how lactate modulates the TRPV1 regarded as the main sensor for acidosis in sensory neurons. In this study we investigated the effects of lactate (LA) on recombinant and native TRPV1 channels and on TRPV1-mediated release of neuropeptides from mouse nerves. TRPV1-mediated membrane currents evoked by protons, capsaicin or heat are inhibited by LA at concentrations ranging from 3 μM to 100 mM. LA inhibits TRPV1-mediated proton-induced Ca²⁺-influx in dorsal root ganglion neurons as well as proton-evoked

SUBMITTER: de la Roche J 

PROVIDER: S-EPMC5101504 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature