Evidence for a dynamic role for mononuclear phagocytes during endometrial repair and remodelling.

ABSTRACT: In women, endometrial breakdown, which is experienced as menstruation, is characterised by high concentrations of inflammatory mediators and immune cells which account for ~40% of the stromal compartment during tissue shedding. These inflammatory cells are known to play a pivotal role in tissue breakdown but their contribution to the rapid scarless repair of endometrium remains poorly understood. In the current study we used a mouse model of menstruation to investigate dynamic changes in mononuclear phagocytes during endometrial repair and remodelling. Menstruation was simulated in MacGreen mice to allow visualisation of CSF1R⁺ mononuclear phagocytes. Immunohistochemistry revealed dynamic spatio-temporal changes in numbers and location of CSF1R-EGFP⁺ cells and Ly6G

SUBMITTER: Cousins FL 

PROVIDER: S-EPMC5101509 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature