Brain-Derived Neurotrophic Factor Val66Met Human Polymorphism Impairs the Beneficial Exercise-Induced Neurobiological Changes in Mice.

ABSTRACT: Several studies have shown that exercise improves cognitive functions and emotional behaviors. Positive effects of exercise have been associated with enhanced brain plasticity, adult hippocampal neurogenesis, and increased levels of brain-derived neurotrophic factor (BDNF). However, a substantial variability of individual response to exercise has been described, which may be accounted for by individual genetic variants. Here, we have assessed whether and how the common human BDNF Val66Met polymorphism influences the neurobiological effects modulated by exercise in BDNF Val66Met knock-in male mice. Wild-type (BDNF^Val/Val) and homozygous BDNF Val66Met (BDNF^Met/Met) male mice were housed in cages equipped with or without running wheels for 4 weeks. Changes in behavioral

SUBMITTER: Ieraci A 

PROVIDER: S-EPMC5101555 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature