Plasmodium vivax multidrug resistance-1 gene polymorphism in French Guiana.

ABSTRACT:

Background

Plasmodium vivax malaria is a major public health problem in French Guiana. Some cases of resistance to chloroquine, the first-line treatment used against P. vivax malaria, have been described in the Brazilian Amazon region. The aim of this study is to investigate a possible dispersion of chloroquine-resistant P. vivax isolates in French Guiana. The genotype, polymorphism and copy number variation, of the P. vivax multidrug resistance gene-1 (pvmdr1) have been previously associated with modification of the susceptibility to chloroquine.

Methods

The pvmdr1 gene polymorphism was evaluated by sequencing and copy number variation was assessed by real-time PCR, in P. vivax isolates obtained from 591 symptomatic patients from 1997 to 2013.

Results

The results rev

SUBMITTER: Faway E 

PROVIDER: S-EPMC5101641 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature