Fermentative production and direct extraction of (-)-α-bisabolol in metabolically engineered Escherichia coli.

ABSTRACT:

Background

(-)-α-Bisabolol, also known as levomenol, is an unsaturated sesquiterpene alcohol that has mainly been used in pharmaceutical and cosmetic products due to its anti-inflammatory and skin-soothing properties. (-)-α-Bisabolol is currently manufactured mainly by steam-distillation of the essential oils extracted from the Brazilian candeia tree that is under threat because its natural habitat is constantly shrinking. Therefore, microbial production of (-)-α-bisabolol plays a key role in the development of its sustainable production from renewable feedstock.

Results

Here, we created an Escherichia coli strain producing (-)-α-bisabolol at high titer and developed an in situ extraction method of (-)-α-bisabolol, using natural vegetable oils. We expressed a recently identi

SUBMITTER: Han GH 

PROVIDER: S-EPMC5101696 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature