Identification of novel and differentially expressed MicroRNAs in goat enzootic nasal adenocarcinoma.

ABSTRACT:

Background

MicroRNAs (miRNAs) post-transcriptionally regulate a variety of genes involved in eukaryotic cell growth, development, metabolism and other biological processes, and numerous miRNAs are implicated in the initiation and progression of cancer. Enzootic nasal adenocarcinoma (ENA), an epithelial tumor induced in goats and sheep by enzootic nasal tumor virus (ENTV), is a chronic, progressive, contact transmitted disease.

Methods

In this work, small RNA Illumina high-throughput sequencing was used to construct a goat nasal miRNA library. This study aimed to identify novel and differentially expressed miRNAs in the tumor and para-carcinoma nasal tissues of Nanjiang yellow goats with ENA.

Results

Four hundred six known miRNAs and 29 novel miRNAs were identified. A

SUBMITTER: Wang B 

PROVIDER: S-EPMC5101819 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature