Differences in atrial fibrillation‑associated proteins between the left and right atrial appendages from patients with rheumatic mitral valve disease: A comparative proteomic analysis.

ABSTRACT: The majority of proteomic studies have focused on identifying atrial fibrillation (AF)-associated proteins in the right atrium (RA), thus potential differences in AF‑associated proteins between the RA and left atrium (LA) remain unknown. The aim of the present study was to perform proteomic analysis to compare the potential differences in AF‑associated proteins between the right atrial appendage (RAA) and left atrial appendage (LAA) in patients with rheumatic mitral valve disease (RMVD). RAA and LAA tissues were obtained from 18 patients with RMVD (10 with AF) during mitral valve replacement surgery. Two‑dimensional fluorescence difference gel electrophoresis (2‑D DIGE) proteomics analysis was performed using these tissues to identify AF‑associated proteins in RAA and LAA. Subsequently, th

SUBMITTER: Liu H 

PROVIDER: S-EPMC5101960 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature