In Vitro Cytotoxicity, Adhesion, and Proliferation of Human Vascular Cells Exposed to Zinc.

ABSTRACT: Zinc (Zn) and its alloys have recently been introduced as a new class of biodegradable metals with potential application in biodegradable vascular stents. Although an in vivo feasibility study pointed to outstanding biocompatibility of Zn-based implants in vascular environments, a thorough understanding of how Zn and Zn²⁺ affect surrounding cells is lacking. In this comparative study, three vascular cell types-human endothelial cells (HAEC), human aortic smooth muscle cells (AoSMC), and human dermal fibroblasts (hDF)-were studied to advance the understanding of Zn/Zn²⁺-cell interactions. Aqueous cytotoxicity using a Zn²⁺ insult assay resulted in LD₅₀ values of 50 µM for hDF, 70 µM for AoSMC, and 265 µM for HAEC. Direct cell contact with the metal

SUBMITTER: Shearier ER 

PROVIDER: S-EPMC5102339 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature