Altered local spontaneous activity in frontal lobe epilepsy: a resting-state functional magnetic resonance imaging study.

ABSTRACT:

Purpose

The purpose of this study was to investigate the local spatiotemporal consistency of spontaneous brain activity in patients with frontal lobe epilepsy (FLE).

Method

Eyes closed resting-state functional magnetic resonance imaging (fMRI) data were collected from 19 FLE patients and 19 age- and gender-matched healthy controls. A novel measure, named FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) was used to assess the spatiotemporal consistency of local spontaneous activity (emphasizing both local temporal homogeneity and regional stability of brain activity states). Then, two-sample t test was performed to detect the FOCA differences between two groups. Partial correlations between the FOCA values and durations of epilepsy were f

SUBMITTER: Dong L 

PROVIDER: S-EPMC5102650 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature