An ω-3-enriched diet alone does not attenuate CCl₄-induced hepatic fibrosis.

ABSTRACT: Exposure to the halogenated hydrocarbon carbon tetrachloride (CCl₄) leads to hepatic lipid peroxidation, inflammation and fibrosis. Dietary supplementation of ω-3 fatty acids has been increasingly advocated as being generally anti-inflammatory, though its effect in models of liver fibrosis is mixed. This raises the question of whether diets high in ω-3 fatty acids will result in a greater sensitivity or resistance to liver fibrosis as a result of environmental toxicants like CCl₄. In this study, we fed CCl₄-treated mice a high ω-3 diet (using a mix of docosahexaenoic acid and eicosapentaenoic acid ethyl esters). We also co-administered an inhibitor of soluble epoxide hydrolase, 1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), which has be

SUBMITTER: Harris TR 

PROVIDER: S-EPMC5102762 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature