Youth with substance abuse histories exhibit dysfunctional representation of expected value during a passive avoidance task.

ABSTRACT: Individuals with substance abuse (SA) histories show impairment in the computations necessary for decision-making, including expected value (EV) and prediction error (PE). Neuroimaging findings, however, have been inconsistent. Sixteen youth with (SA_positive) and 29 youth without (SA_negative) substance abuse histories completed a passive avoidance task while undergoing functional MRI. The groups did not significantly differ on age, gender composition or IQ. Behavioral results indicated that SA_positive youth showed significantly less learning than SA_negative youth over the task. SA_positive youth show problems representing EV information when attempting to avoid sub-optimal choices in bilateral inferior frontal gyrus and striatum. Furthe

SUBMITTER: White SF 

PROVIDER: S-EPMC5102791 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature