Individual behavioral and neurochemical markers of unadapted decision-making processes in healthy inbred mice.

ABSTRACT: One of the hallmarks of decision-making processes is the inter-individual variability between healthy subjects. These behavioral patterns could constitute risk factors for the development of psychiatric disorders. Therefore, finding predictive markers of safe or risky decision-making is an important challenge for psychiatry research. We set up a mouse gambling task (MGT)-adapted from the human Iowa gambling task with uncertain contingencies between response and outcome that furthermore enables the emergence of inter-individual differences. Mice (n = 54) were further individually characterized for locomotive, emotional and cognitive behavior. Individual basal rates of monoamines and brain activation after the MGT were assessed in brain regions related to reward, emotion or cognition. In a l

SUBMITTER: Pittaras E 

PROVIDER: S-EPMC5102946 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature