Biochemical and Electrophysiological Modification of Amyloid Transthyretin on Cardiomyocytes.

ABSTRACT: Transthyretin (TTR) amyloidoses are familial or sporadic degenerative conditions that often feature heavy cardiac involvement. Presently, no effective pharmacological therapy for TTR amyloidoses is available, mostly due to a substantial lack of knowledge about both the molecular mechanisms of TTR aggregation in tissue and the ensuing functional and viability modifications that occur in aggregate-exposed cells. TTR amyloidoses are of particular interest regarding the relation between functional and viability impairment in aggregate-exposed excitable cells such as peripheral neurons and cardiomyocytes. In particular, the latter cells provide an opportunity to investigate in parallel the electrophysiological and biochemical modifications that take place when the cells are exposed for various

SUBMITTER: Sartiani L 

PROVIDER: S-EPMC5103001 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature