Pade Approximation of a Stationary Single-Channel Ca²⁺ Nanodomain.

ABSTRACT: We consider the stationary solution for the Ca²⁺ concentration near a point Ca²⁺ source describing a single-channel Ca²⁺ nanodomain, in the presence of a single mobile buffer with one-to-one Ca²⁺ binding stoichiometry. Previously, a number of Ca²⁺ nanodomains approximations have been developed, for instance the excess buffer approximation (EBA), the rapid buffering approximation (RBA), and the linear approximation (LIN), each valid for appropriate buffering conditions. Apart from providing a simple method of estimating Ca²⁺ and buffer concentrations without resorting to computationally expensive numerical solution of reaction-diffusion equations, such approximations proved useful in revealing the dependence of nanodomain Ca<

SUBMITTER: Matveev V 

PROVIDER: S-EPMC5103006 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature