An Integrated Stochastic Model of Matrix-Stiffness-Dependent Filopodial Dynamics.

ABSTRACT: The ways that living cells regulate their behavior in response to their local mechanical environment underlie growth, development, and healing and are important to critical pathologies such as metastasis and fibrosis. Although extensive experimental evidence supports the hypothesis that this regulation is governed by the dependence of filopodial dynamics upon extracellular matrix stiffness, the pathways for this dependence are unclear. We therefore developed a model to relate filopodial focal adhesion dynamics to integrin-mediated Rho signaling kinetics. Results showed that focal adhesion maturation, i.e., focal adhesion links reinforcement and integrin clustering, dominates over filopodial dynamics. Downregulated focal adhesion maturation leads to the biphasic relationship between extrace

SUBMITTER: Cheng B 

PROVIDER: S-EPMC5103017 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature