A Novel Spirometric Measure Identifies Mild COPD Unidentified by Standard Criteria.

ABSTRACT:

Background

In chronic obstructive pulmonary disease, both smaller and larger airways are affected. FEV₁ mainly reflects large airways obstruction, while the later fraction of forced exhalation reflects reduction in terminal expiratory flow. In this study, the objective was to evaluate the relationship between spirometric ratios, including the ratio of forced expiratory volume in 3 and 6 seconds (FEV₃/FEV₆), and small airways measures and gas trapping at quantitative chest CT scanning, and clinical outcomes in the Genetic Epidemiology of COPD (COPDGene) cohort.

Methods

Seven thousand eight hundred fifty-three current and ex-smokers were evaluated for airflow obstruction by using recently defined linear iteratively derived equations of Hansen e

SUBMITTER: Dilektasli AG 

PROVIDER: S-EPMC5103018 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature