An immunostimulatory dual-functional nanocarrier that improves cancer immunochemotherapy.

ABSTRACT: Immunochemotherapy combines a chemotherapeutic agent with an immune-modulating agent and represents an attractive approach to improve cancer therapy. However, the success of immunochemotherapy is hampered by the lack of a strategy to effectively co-deliver the two therapeutics to the tumours. Here we report the development of a dual-functional, immunostimulatory nanomicellar carrier that is based on a prodrug conjugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently used for reversing tumour immune suppression. An Fmoc group, an effective drug-interactive motif, is also introduced into the carrier to improve the drug loading capacity and formulation stability. We show that PEG_2k-Fmoc-NLG alone is effective in enhancing T-cell immune responses and exh

SUBMITTER: Chen Y 

PROVIDER: S-EPMC5103075 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature