Adaptation of Akkermansia muciniphila to the Oxic-Anoxic Interface of the Mucus Layer.

ABSTRACT: Akkermansia muciniphila colonizes the mucus layer of the gastrointestinal tract, where the organism can be exposed to the oxygen that diffuses from epithelial cells. To understand how A. muciniphila is able to survive and grow at this oxic-anoxic interface, its oxygen tolerance and response and reduction capacities were studied. A. muciniphila was found to be oxygen tolerant. On top of this, under aerated conditions, A. muciniphila showed significant oxygen reduction capacities and its growth rate and yield were increased compared to those seen under strict anaerobic conditions. Transcriptome analysis revealed an initial oxygen stress response upon exposure to oxygen. Thereafter, genes related to respiration were expressed, including those coding for the cytochr

SUBMITTER: Ouwerkerk JP 

PROVIDER: S-EPMC5103097 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature