Repetition suppression in the medial temporal lobe and midbrain is altered by event overlap.

ABSTRACT: Repeated encounters with the same event typically lead to decreased activation in the medial temporal lobe (MTL) and dopaminergic midbrain, a phenomenon known as repetition suppression. In contrast, encountering an event that overlaps with prior experience leads to increased response in the same regions. Such increased responding is thought to reflect an associative novelty signal that promotes memory updating to resolve differences between current events and stored memories. Here, we married these ideas to test whether event overlap significantly modulates MTL and midbrain responses-even when events are repeated and expected-to promote memory updating through integration. While undergoing high-resolution functional MRI, participants were repeatedly presented with objects pairs, some of wh

SUBMITTER: Zeithamova D 

PROVIDER: S-EPMC5103173 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature