Parasitological correlates of Plasmodium ovale curtisi and Plasmodium ovale wallikeri infection.

ABSTRACT:

Background

Malaria, due to Plasmodium ovale, can be challenging to diagnose due to clinically mild disease and low parasite burden. Two genetically distinct sub-species of P. ovale exist: Plasmodium ovale curtisi (classic) and Plasmodium ovale wallikeri (variant). It is presently unknown if the sub-species causing infection affects performance of malaria diagnostic tests. The aim of this work was to understand how the genetically distinct sub-species, P. o. curtisi and P. o. wallikeri, affect malaria diagnostic tests.

Methods

Plasmodium ovale-positive whole blood specimens were sub-speciated by PCR and sequencing of 18S rRNA and dhfr-ts. Parasitaemia, morphology, pan-aldolase positivity, 18S copy number, and dhfr-ts sequences were compared between sub-species.

Results

SUBMITTER: Phuong MS 

PROVIDER: S-EPMC5103354 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature