Prolactin related symptoms during risperidone maintenance treatment: results from a prospective, multicenter study of schizophrenia.

ABSTRACT:

Background

This study aimed to investigate prolactin related symptoms (PRS) in individuals with schizophrenia during risperidone maintenance treatment for one year, as well as to identify the risk factors for PRS.

Methods

In a multicenter, randomized, controlled, longitudinal study, clinically stabilized schizophrenia patients (N = 374) were randomized to a no-dose-reduction group (N = 129) and 4-week (N = 125) and 26-week (N = 120) reduction groups, in which the original dose was followed by a 50 % reduction over 8 weeks and subsequently maintained. PRS were assessed via a scale of prolactin related adverse events, which included 16 items: menstrual cycle, menstrual period, menstrual volume, menstrual irregularities, amenorrhea, dysmenorrhea, postpartum lactation, gynecomas

SUBMITTER: Bo Q 

PROVIDER: S-EPMC5103401 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature